| Chapter # | Patient Safety Target | Patient Safety Practice | Impact | Study Strength | Effect Size | Vigilance | Cost | Complexity |
| 6 | Medication errors and adverse drug events (ADEs) primarily related to ordering process | Computerized physician order entry (CPOE) with clinical decision support system (CDSS) | High | Medium1 | Modest | Medium | High2 | High |
| 7 | Medication errors and ADEs related to ordering and monitoring | Clinical pharmacist consultation services | High | Medium | Modest3 | Low | High | Low |
| 8 | ADEs related to targeted classes (analgesics, KCl, antibiotics, heparin) (focus on detection) | Use of computer monitoring for potential ADEs | Medium | Medium | Robust4 | Low | Medium5 | Low |
| 9 | Adverse events related to anticoagulation | Protocols for high risk drugs: nomograms for heparin | Medium | Medium6 | Robust7 | Medium | Low | Low |
| 9 | Adverse events related to anticoagulation | Anticoagulation services and clinics for coumadin8 | High | Medium | Unclear | Low | Medium | Low |
| 9 | Adverse events related to chronic anticoagulation with warfarin | Patient self-management using home monitoring devices | High | High | Robust | Medium | Medium9 | High10 |
| 10 | ADEs in dispensing medications | Unit-dosing distribution system | Medium11 | Medium | Unclear | Low | Low | Low |
| 11 | ADEs in drug dispensing and/or administration | Use of automated medication dispensing devices | High | Medium12 | Unclear | Medium | Medium13 | Low |
| 12 | Hospital-acquired infections | Improved handwashing compliance (via education/behavior change; sink technology and placement; washing substance) | High | Medium14 | Unclear15 | Low | Low | Low16 |
| 13 | Serious nosocomial infections (e.g., vancomycin-resistant enterococcus, C. difficile) | Barrier precautions (via gowns & gloves; dedicated equipment; dedicated personnel) | High | Medium17 | Robust | Medium18 | Medium | Low19 |
| 14 | Hospital-acquired infections due to antibiotic-resistant organisms | Limitations placed on antibiotic use | High20 | Medium | Modest | Medium21 | Low | Low |
| 15.1 | Hospital-acquired urinary tract infection | Use of silver alloy-coated catheters | High | High | Unclear22 | Low | Low | Low |
| 15.2 | Hospital-acquired urinary tract infection | Use of suprapubic catheters | High | High | Unclear23 | Medium | High | High |
| 16.1 | Central venous catheter-related blood infections | Use of maximum sterile barriers during catheter insertion | Medium | High | Robust | Low | Low | Low24 |
| 16.2 | Central venous catheter-related blood infections | Antibiotic-impregnated catheters | Medium | High | Robust | Low25 | Low | Low |
| 16.3 | Central venous catheter-related blood infections | Cleaning site (povidone-iodine to chlorhexidine) | Medium | High | Unclear | Low | Low | Low |
| 16.4 | Central venous catheter-related blood infections | Changing catheters routinely | Medium | High | Negligible± | NA | High | High |
| 16.4 | Central venous catheter-related blood infections | Use of heparin | Medium | High | Unclear | Medium | Low | Low |
| 16.4 | Central venous catheter-related blood infections | Tunneling short-term central venous catheters | Medium | High | Unclear | Low | Low | High |
| 16.4 | Central venous catheter-related blood infections | Routine antibiotic prophylaxis | Medium | Medium | Negligible | Medium | Medium | Low |
| 17.1 | Ventilator-associated pneumonia | Semi-recumbent positioning | High | Medium | Robust26 | Low | Low | Low |
| 17.1 | Ventilator-associated pneumonia | Continuous oscillation | High | High | Robust27 | Medium | Medium | Low |
| 17.2 | Ventilator-associated pneumonia | Continuous aspiration of subglottic secretions (CASS) | High | High | Robust28 | Low | Low | High29 |
| 17.3 | Ventilator-associated pneumonia | Selective decontamination of digestive tract | High | High | Robust30 | Medium31 | Low | Low |
| 17.4 | Ventilator-associated pneumonia | Sucralfate | High | High | Unclear | High32 | Low | Low |
| 18 | Mortality associated with surgical procedures | Localizing specific surgeries and procedures to high volume centers | High | Medium33 | Varies | Medium | Varies | High |
| 20.1 | Surgical site infections | Appropriate use of antibiotic prophylaxis | Medium34 | High | Robust | Medium35 | Low | Low |
| 20.2 | Surgical site infections | Maintenance of perioperative normothermia | High | Medium36 | Robust | Medium37 | Low | Low |
| 20.3 | Surgical site infections | Use of supplemental perioperative oxygen | High | Medium38 | Robust | Low | Low | Low |
| 20.4 | Surgical site infections | Perioperative glucose control | High | Medium | Robust | Medium | Low | High39 |
| 21 | Morbidity due to central venous catheter insertion | Use of real-time ultrasound guidance during central line insertion | High | High | Robust40 | Low41 | Medium | High |
| 22 | Surgical items left inside patient | Counting sharps, instruments, sponges | Insuff. Info.42 | Low | Not rated | Not rated | Low | Low |
| 23 | Complications due to anesthesia equipment failures | Use of preoperative anesthesia checklists | Low43 | Low | Not rated | Not rated | Low | Low |
| 24 | Critical events in anesthesia | Intraoperative monitoring of vital signs and oxygenation | Low44 | Medium45 | Unclear46 | Low | Low | Low |
| 25 | Perioperative cardiac events in patients undergoing noncardiac surgery | Use of perioperative beta-blockers | High | High | Robust | Medium | Low | Low |
| 26.1 | Falls | Use of identification bracelets | Medium | Medium | Negligible | Low | Low | Low |
| 26.2 | Restraint-related injuries; Falls | Interventions to reduce the use of physical restraints safely | Medium | Medium | Unclear47 | Medium | Medium | Low |
| 26.3 | Falls | Use of bed alarms | Medium | Medium | Unclear | Low48 | Medium49 | Low |
| 26.4 | Falls and fall-related injuries | Use of special flooring material in patient care areas | Medium | Low | Not rated | Not rated | High | Low |
| 26.5 | Falls and fall injuries | Use of hip protectors | Medium | High | Robust | Medium | Low50 | Low51 |
| 27 | Pressure ulcers | Use of pressure relieving bedding materials | High | High | Robust52 | Low | High | Low |
| 28 | Hospital-related delirium | Multi-component delirium prevention program | High | Medium | Robust | Low | Medium | Low |
| 29 | Hospital-acquired complications (e.g., falls, delirium, functional decline, mortality) | Geriatric consultation services | High | High | Varies53 | Low | Medium | High |