Methodological Issues in Outcome Research (Text Version)

Slide Presentation from the AHRQ 2008 Annual Conference

On September 9, 2008, John D. Seeger, Sebastian Schneeweiss and Alan M. Brookhart, made this presentation at the 2008 Annual Conference. Select to access the PowerPoint® presentation (326 KB).

Slide 1

Methodological Issues in Outcome Research

Effective Healthcare
AHRQ 2008 Conference
September 7-10, 2008.

Slide 2

Purpose

• To discuss state of the art analytical approaches to adjust for confounding in observational research within the Effective Health Care Program.
  • Measured confounders: Propensity score.
  • Unmeasured confounders:
    • Sensitivity analysis.
    • Instrumental variables.

Slide 3

Panelists

• John D. Seeger, PharmD., DrPH.
  • Senior scientist, Ingenix/i3 Drug Safety.
  • Transparency in the Use of Propensity Score Methods.
• Sebastian Schneeweiss, M.D., ScD.
  • Department of Medicine, Harvard Medical School.
  • Principal Investigator of Brigham and Women's Hospital Developing Evidence to Inform Decisions about Effectiveness (DEcIDE) Center.
  • Sensitivity Analysis for Residual Confounding.
• Alan M. Brookhart, Ph.D.
  • Brigham and Women's Hospital, Harvard Medical School.
  • Instrumental variable analysis for comparative effectiveness research.

Slide 4

Ground Rules

• Each panelist will present for ~20-25 minutes.
• Questions and comments should be made at the end of session.
• If you have a question, please come to the microphone if possible.
• Please identify the panelist to whom the question is addressed.