Summaries of Independent Scientist (K) Awards

Siderowf, Andrew

Institution: University of Pennsylvania
Grant Title: Health Preference Assessment in Parkinson's Disease
Grant Number:  K08 HS00004
Duration: 5 years (2000-2005)
Total Award: $644,700

Project Description: The project had three main goals:

1. To produce a series of vignettes describing Parkinson's Disease (PD)-related health states, and to elicit societal preference weights for these vignettes.
2. To conduct a cross sectional study comparing this set of preferences to values derived from pre-scored multi-attribute health classification systems, and to preferences elicited from patients and caregivers.
3. To conduct a longitudinal study to measure reliability and responsiveness of preference-based measures in PD patients and their caregivers.

Career Goals: Dr. Siderowf is an Associate Professor of Neurology at the University of  Pennsylvania School of Medicine.  He received his M.D. from Duke University and did his residency in neurology at the Hospital of the University of Pennsylvania.  He was then a Fellow in Parkinson's Disease and Experimental Therapeutics at the University of Rochester Medical School.  During his K award period, Dr. Siderowf completed the degree requirements for the Master of Science in Clinical Epidemiology.  The grantee has committed his career to bringing the methods of health services research to the clinical area of Parkinson's Disease and related disorders.

Progress to Date: This grant has been completed.  Analysis of the data collected in the longitudinal study of preference-based measures shows that directly elicited preferences (utilities) vary substantially among Parkinson's patients, and are not strongly related to measures of clinical disease severity.  With the exception of the rating-scale method, all directly elicited methods were difficult for patients to complete and were received with skepticism.  This was particularly true of the willingness to pay exercise.  In general, it appears that the pre-scored instruments are more reliable and feasible in PD patients than the directly elicited measures, with the exception of the rating scale method.

Highlights and Specific Accomplishments:

• Panels and Committees by Invitation:
  • 2002 Data Safety Monitoring Committee, "Transcription and Therapy for Huntington's Disease  (Steven M. Hersch, M.D., Ph.D., Principal Investigator, National Institute of Neurological Disorders and Stroke (NINDS) Program Project, Grant NS45242).
  • 2003 Symposium Committee; Parkinson Study Group.
• Professional Societies:
  • American Academy of Neurology.
  • Movement Disorders Society.
• Invitational Lectures:
  • February 12, 2004, "Treatment of Hyperkinetic Movement Disorders." Penn Neurology 2004 CME Course, San Juan PR.
  • March 12, 2004, "Follow-up Management after DBS." Philadelphia DBS Programming Seminar, Philadelphia.
  • April 2, 2005, "Practical Management of Parkinson's Disease." St. Joseph's Medical Center, Towson, MD.
  • April 12, 2005, "Update on Parkinson's Disease," Syracuse Community General Hospital, Syracuse, NY.

K-Generated Publications (selected):

Holloway R, Siderowf A.  Evidence-based neurotherapeutics:  A spectrum of evidence. NeuroRx 2004. 1:295-97.

Siderowf A. Evidence from clinical trials:  Can we do better?  NeuroRx 2004. 1:363-71.

Lynch DR, Mozley PD, Sokol S, Maas NMC, Balcer LJ, Siderowf AD. Lack of effect of polymorphisms in dopamine metabolism related genes on imaging of TRODAT-1 in striatum of asymptomatic volunteers and patients with Parkinson's Disease. Movement Disorders 2003. 18:804-11.

Siderowf A, Stern MB. Update on Parkinson's Disease. Annals of Internal Medicine 2003. 138;651-58.

Elman L, Siderowf A. McCLuskey L. Nocturnal Oximetry: Utility in respiratory management of ALS. Journal of Physical Medicine and Rehabilitation 2003. 82(11):866-70.

Cheng EM, Siderowf AM, Swarztrauber K, Elisa M, Lee M, Vickrey BG. Development of quality of care indicators for Parkinson's Disease. Movement Disorders 2004. 19(2):136-50.

Siderowf AM, Jaggi JL, Xie SX, et al. Long-term effects of bilateral subthalamic nucleus stimulation on health-related quality of life in advanced Parkinson's Disease. Movement Disorders 2006. 21(6):746-53

Ravina B, Putt, M, Siderowf AD, et al. Donepezil for dementia in Parkinson's Disease: a randomized, double blind, placebo controlled, crossover study. Journal of Neurology, Neurosurgery, and Psychiatry 2005. 76:934-39.

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