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Summaries of Independent Scientist (K) Awards

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Lightdale, Jenifer

Institution: Children's Hospital Boston
Grant Title: Improving Safety of Pediatric Sedation
Grant Number: K08 HS013675
Duration: 4 years (2003-2007)
Total Award: $629,000

Project Description: This proposal had three main goals:

Use robust, precise methods to prospectively assess intolerance, other adverse events and medical errors during sedation for gastrointestinal (GI) endoscopy.
Utilize regression modeling to develop prediction rules to improve the safety of sedation for children undergoing this procedure.
Tailor existing taxonomies to classify medical errors associated with IV sedation for GI endoscopy.

Career Goals: Dr. Lightdale is an Assistant Professor in Pediatrics at Children's Hospital Boston. She received her MD from Mount Sinai School of Medicine and completed her residency in Pediatrics at the University of California, San Francisco (UCSF), and was awarded a fellowship in Pediatric Gastroenterology and Nutrition at Harvard. She plans to continue research focused in the area of healthcare delivery and improvement. She has become a leader in patient safety research, gastrointestinal endoscopy and pediatric sedation.

Progress to Date: This grant has been completed. Findings suggested a clinically significant number of children appear agitated during procedural sedation and analgesia, increasing their risk for more traditional adverse events. Capnography may provide early warning for impending respiratory compromise.

K-Generated Publications (selected):

Lightdale JR. Sedation and analgesia in the pediatric patient. Gastrolintestinal Endoscopy Clinics of North America 2004. 14(2):385-99

Mahoney, LB, Lightdale JR. Sedation of the pediatric and adolescent patient for GI procedures. Current Treatment Options in Gastroenterology 2007. 5:412-21.

Lightdale JR, Goldmann DA, Feldman HA, et al. Microstream capnography improves patient monitoring during moderate sedation: A randomized controlled trial. Pediatrics 2006. 117(6):1170-78.

Schwarz SM, Lightdale JR, Liacouras CA. Sedation and anesthesia in pediatric endoscopy: One size does not fit all. Journal of Pediatric Gastroenterology and Nutrition 2007. 44(1):1-3.

Bannerjee, S, Bishop W, Valim C, Mahoney LB, Lightdale JR. Percutaneous liver biopsy practice patterns among pediatric gastroenterologists in North America. Journal of Pediatric Gastroenterology and Nutrition 2007. 45(1):84-9.

Lightdale JR, Mahoney LB, Schwarz SM, Lacouras CA. Methods of sedation in pediatric endoscopy: A survey of NASPGHAN members. Journal of Pediatric Gastroenterology and Nutrition 2007. 45:500-02.

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