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Table 3. Primary Prevention Trials of Drug Therapy: Results*
| Study details |
LRC (34) |
Helsinki (35) |
WOSCOPS (36) |
AFCAPS(37) |
| Year |
1984 |
1987 |
1995 |
1998 |
| Main outcome |
Nonfatal MI, CHD death |
Nonfatal MI, CHD death |
Nonfatal MI, CHD death |
Nonfatal MI, CHD death,
unstable angina |
| Cumulative event ratea |
8.1/9.8 |
2.73/4.14 |
5.5/7.9 |
3.4/5.45 |
| I/C |
(5.5/6.6)b |
|
|
1.65/2.9c |
| ARR |
1.7 (1.1)b |
1.41 |
2.4 |
2.05 (1.25)c |
| NNT for 5 yearse |
(91)b |
71 |
42 |
49 (80)c |
| RRR (%) |
19 |
34 |
31 |
37 |
| (95% CI) |
(3-32)d |
(8-53) |
(17-43) |
(21-50) |
[a] Event rates are cumulative incidence in percentages for the event over the study; I, intervention, C, control.
[b] Adjusted 5-year outcomes for LRC.
[c] Unstable angina excluded in results.
[d] CI for LRC was 90%.
[e] NNT for 5 years to prevent 1 CHD event.
*LRC, Lipids Research Council; HHS, Helsinki Heart Study; WOSCOPS, West of Scotland Coronary Prevention Study; AFCAPS, Air Force/Texas Coronary Atherosclerosis Prevention; MI, myocardial infarction; CHD, coronary heart disease; ARR, absolute risk reduction; NNT, numbers needed to treat; RRR, relative risk reduction; CI, confidence interval.
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